Mast cell activation syndrome
Mast cell what? Don’t worry, we don’t blame you if you haven’t heard of it! First, let’s talk mast cells. Mast cells are a type of immune cell that originate in the bone marrow and are found in most tissues. They play a role in both health and disease, and are most commonly known for their role in atopic disorders (aka allergies) and anaphylaxis. When they’re functioning normally, mast cells release chemicals that help protect the body—they’re like first responders for your immune system. But when they’re not properly regulated, mast cells have been linked to several chronic allergic/inflammatory disorders, autoimmune diseases, and cancers. If you have mast cell activation syndrome (MCAS), your mast cells overreact and release chemicals when they shouldn’t. Often, they treat food, fragrances, temperature, and even stress as something to “defend against.” Depending on which chemical the mast cells release, you can experience a whole range of symptoms, including hives, diarrhea, shortness of breath, fatigue, brain fog, congestion, lightheadedness, and much more. MCAS may even cause anaphylaxis, a medical emergency. And it may pop up in people who have Ehlers Danlos Syndrome (EDS), which is a connective tissue disorder, or Postural Orthostatic Tachycardia Syndrome (POTS). MCAS is difficult to diagnose and treatment response varies. If you have MCAS, try to avoid substances and environments that may provoke your symptoms. If a severe anaphylactic reaction occurs, call 911 right away—you’ll need to be treated emergently with epinephrine. Antihistamines, H2 blockers, mast cell stabilizers, and steroids are also used to help treat the symptoms. Your mast cells are just trying to do their job and keep you safe, but as is often the case, the immune system can take it too far!
Recent posts about Mast cell activation syndrome
hey fam. I got some difficult news this week😞. Turns out I have EDS, Mast Cell Activation Syndrome, Fibromyalgia and now I am seeing another Dr about possibly POTS and Small Fiber Neuropathy. I already knew about the fibro and painful joints but these new diagnostic realities have me a bit shaken. I could really use some love and assurance from you guys! Tips and treatment suggestions welcomed 🥰
Good Morning, question for my Allergy / Asthma friends. I do my best to stay indoors because the heat bothers my POTS and irritates MCAS symptoms. I’m having a terrible asthma flair right now, so I’m trying to avoid any irritation (allergic to every plant). Any advice on how to enjoy the outdoors safely or with less symptoms? I don’t usually miss being outdoors because it bothers me so much, but we just bought a house and I would love to enjoy my cute, new porch more with my fiance!
Been on a very long journey with gut issues, migraines, etc since I was young. Now the last 4 years have been debilitating. Hearing loss, POTS, and being tested for MCAS and vascular collagen issues. Constantly getting flares that feel like I’m going to pass out, heart racing, choking and no one knows what to do. Not even specialists
My period is coming and I usually have horrible pain the first day. My mast cell activation syndrome has been quite bad lately so there is no pain killer I can take! 🤦🏻♀️😳 I can't do baths because of POTS, but I like heating pads. More in comments...
Hi! I have a friend who has endometriosis & mast cell activation syndrome (and recently had carbon monoxide poisoning). Is it possible to add her to this beta? She’s at her whit’s end.
Videos about Mast cell activation syndrome
MAST CELL ACTIVATION SYNDROME TREATMENT SUCCESS WITH STEM CELL: 7-Revolutionary Breakthroughs!
Dr. Michael Johnson
Books about Mast cell activation syndrome
Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity
In 2008 Dr. Afrin started coming to understand that a newly recognized type of mast cell disease, now called mast cell activation syndrome (MCAS), was the underlying diagnosis in many patients he was seeing who were each suffering large assortments -- quite different from one patient to the next -- of chronic multisystem inflammatory illnesses of unclear cause. Dr. Afrin soon gained experience that MCAS is far more prevalent than the only mast cell disease previously known to medicine (the rare disease of mastocytosis) and that most MCAS patients, once accurately diagnosed, can eventually find significantly helpful medications targeted at the disease. The frequency and magnitude of the improvements Dr. Afrin has seen -- even the relief that comes from finally having a unifying diagnosis other than psychosomatism -- have spurred him to focus in this area, not only tending to the needs of his patients but also pursuing research to advance our understanding of the disease and helping to educate other professionals who in turn can help even more of the many people who have long been suffering not only the symptoms of the disease but also the natural concern of not understanding why one would be so "unlucky" to have acquired so many medical problems. As it turns out, such patients are not so unlucky and truly have just one root issue (and a very common one at that), which has the biological capability to develop, directly or indirectly, into most or all of their previously diagnosed problems. There is a great deal yet to learn about this, but even with just the present very limited understanding, the opportunity to diagnose and help patients with MCAS seems to be enormous and Dr. Afrin felt a description of the disease, written for the general public, might help lead some MCAS patients on a journey to diagnosis and improvement sooner rather than later. Dr. Afrin hopes this book will help people who might have, or do have, MCAS. A portion of the proceeds of purchases of this book will go to support research and education in this area.
Podcasts about Mast cell activation syndrome
Dr. Ruscio Radio: Could Mast Cell Activation Syndrome Be the Cause of Your Non-Responsive Symptoms? Simplified Assessment and Treatment Recommendations with Dr. Tania Dempsey
Mast Cell Activation Syndrome (MCAS) is something to consider when you haven’t responded to anything else. Let’s discuss simple methods of treatment and assessment. Specifically a simple questionnaire and a small number of natural or over the counter medications may make a big difference in improving how you feel if you haven’t responded to other treatments you have tried. https://drruscio.com/mcas-symptoms-with-tania-demp… My new book is finally available: Healthy Gut, Healthy You. Click here to learn more: https://drruscio.com/getgutbook/ Looking for more? Check out our resource page that includes how to become a patient, how to pick up a copy of my new book, how to sign up for my clinical training newsletter, and more.
Dr. Ruscio Radio: Histamine Intolerance & Mast Cell Activation Syndrome (MCAS) with Dr. Jill Carnahan
If you feel like you react to everything you eat or take, or you can’t improve no matter what you do, you should consider the possibility of histamine intolerance and/or mast cell activation syndrome. Today Dr. Jill Carnahan and I expand on how to identify histamine intolerance and/or mast cell activation syndrome and some simple steps you can take to address these issues
The SIBO Doctor: SIBO and Mast Cell Activation Syndrome
In this episode, Dr Nirala Jacobi speaks with Heidi Turner on the topic of Mast Cell Activation Syndrome. Heidi is a medical nutrition therapist at the Seattle Arthritis Clinic at Northwest Hospital UW Medicine in Seattle, Washington. She specialises in food intolerances, SIBO, and other digestive disorders, addressing the digestion in order to balance all body systems. In this episode topics include: Using diet to decrease inflammation in the body and improve pain markers for autoimmune patients. Mast cell activation syndrome (MCAS) and the diverse array of signs and symptoms with which it can present. SIBO and how it relates to mast cells disorder and MCAS. What mast cells are and what responses they create within the immune system. Predisposing factors for MCAS The physiological relationship of stressors, and/or emotional trauma to the development of MCAS and other conditions in the body. Histamine Its diverse roles in the body. Intolerance symptoms. How intolerance can develop. High histamine foods. How to best assess patients for histamine intolerance. Antihistamine supplements. Diamine Oxidase (DAO) and SIBO related histamine dysregulation. How to navigate probiotic treatment for highly digestively sensitive patients. Various treatment options for stabilising mast cells, and MCAS specific support.
Sickboy: Slayer of Dragons, Mast Cells & Ehlers-Danlos Syndromes
This week on Sickboy the guys sit down with an 18 year old Knight in shining armour. Literally. Danielle lives with a Mast Cell and Ehlers-Danlos syndrome but that doesn’t stop her from taking part in medieval battles. We dive into the world of L.A.R.P and Brian geeks out a little too much on World of Warcraft. Danielle reminds us of the importance of developing and seeking community in times of need. Oh, and one more thing a real life opera singer stops the studio for a show.
New Frontiers in Functional Medicine: All things Mast Cell with World-Renowned Clinical Researcher Dr. Theoharides
In my Tour de Force conversation with the brilliant Dr. Theoharis Theoharides, we covered all things mast cells, from “bench to bedside.” In case you have not yet encountered his work yet, he is one of the most highly decorated, well-published clinician researchers in the world. The focus of his life’s work has been on all things mast cells, and mast cell associated conditions. Given the meteoric rise in said conditions (and our improved understanding of the role of mast cells in most chronic diseases), as clinicians, we need to understand how to diagnose and treat. Buckle up for this podcast, and get your pen and pad ready – the depth and breadth of Dr. T’s knowledge requires careful listening. Give a listen, then give a thumbs up for this brilliant, generous clinician!
Wellness Women Radio: Mast Cell Activation Syndrome
Have you heard of Mast Cell Activation Syndrome (MCAS)? If you haven’t then it won’t be long before this condition is at the forefront of medical interest! MCAS is a chronic and very serious immune system disorder that presents in many different ways. If you feel like you’re always sick, if you’re allergic to everything, chronically fatigued or you don’t respond to any normal interventions then pay close attention to this episode! Dr Andrea & Dr Ashleigh break down the ins and outs of MCAS and where to turn for help!
Gene Queen Podcast: Mast Cell Issues with Dr. Tim Jackson
Are you the person that flushes easily on your face, neck and chest? Do your ears and feet get hot? Itchy skin with weird rashes? Hives? Headaches? GI distress? Feeling anxious? Trouble sleeping? Can anyone relate? All of these symptoms and more can be tied to problems with a type of cell in our body called mast cells Today we are going to talk about what happens when mast cells misbehave, WHY they misbehave - hint there are deeper issues, what tests need to be run, what genes are important for histamine breakdown, why the probiotic buddies in our bellies are key and what treatment options you have with Dr. Tim Jackson. Dr. Tim Jackson completed his Doctorate in Physical Therapy (DPT) from the Medical University of South Carolina and he is the owner of www.HealYourBody.org. He works with patients all over the world specializing in issues with the nervous and immune system. Along with patients, Dr. Tim Jackson teaches healthcare professionals to implement these advanced techniques into their practices.
Unbound Healing: Understanding Mast Cell Activation Disorder with Dr. Afrin
Today Anne Marie and Michelle interview Dr. Lawrence Afrin, author of Never Bet Against Occam, about his work with patients dealing with Mast Cell Activation Disorder. Dr. Afrin is sharing with us his experience with identifying and treating this disorder from a holistic perspective. Topics What is Mast Cell Activation Disorder? [2:35] The signs and symptoms of MACD [12:10] How can someone find a doctor that will support them through the diagnosis process? [15:55] Environmental triggers or patterns in patients [25:14] Holistic protocols for MCAD [29:58] MCAD and Histamine Intolerance [40:40] Giving your Doctor grace as they may need to learn about this topic being that it’s so new [56:10] Where to find more from Dr. Afrin (exciting advancements in MCAD research and treatment!) [58:00]
BetterHealthGuys: Mast Cell Activation Syndrome with Dr. Jill Carnahan, MD
Why You Should Listen: In this episode, you will learn about Mast Cell Activation Syndrome (MCAS), what triggers it, and how it may be treated. About My Guest: My guest for this episode is Dr. Jill Carnahan, MD. Dr. Carnahan is board certified in both Family Medicine and Integrative Holistic Medicine. She completed her residency at the University of Illinois Program in Family Medicine at Methodist Medical Center and received her medical degree from Loyola University Stritch School of Medicine in Chicago. She received her Bachelor of Science degree in Bio-Engineering at the University of Illinois in Champaign-Urbana. Dr. Carnahan moved to Boulder Colorado in 2010 joining medical partner, Dr. Robert Rountree. She opened her own practice, Flatiron Functional Medicine in Louisville CO to expand the services that she offers to her patients. Dr. Jill Carnahan uses functional medicine to help you find answers to the cause of your illness and the nutritional and biochemical imbalances that may be making you feel ill. Functional medicine is personalized medicine that deals with root cause of disease instead of just treating symptoms. Dr. Jill will search for underlying triggers that are contributing to illness through cutting edge lab testing and tailor the intervention to the specific needs of an individual. She may use diet, supplements, lifestyle changes or medication to treat illness but will seek the most gentle way to help the body restore balance. She seeks to promote wellness and create hope, health and healing. Dr. Carnahan walks her talk. She is both a cancer survivor and recovered CIRS patient after she encountered mold in her practice. Key Takeaways: - What are mast cells and what do they do? - What does a mast cell produce when over-activated? - What are the symptoms of MCAS? - What triggers overactivation of mast cells? - What is the role of environmental toxins and MCAS? - Is there a connection between MCAS and POTS? - What role do food reactions and leaky gut play? - What is the link between MCAS and CIRS? - How is MCAS treated? - Are some probiotics bad for people with MCAS? - What mind-body tools may be helpful with MCAS? Connect With My Guest: http://www.jillcarnahan.com Related Resources: Umbrellux DAO - http://umbrelluxdao.com/ Interview Date: April 7, 2017 Disclaimer: The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.
The PM&R Podcast: Mast Cell Activation Syndrome
Mast cell activation syndrome is a condition that most doctors have never heard about, yet it is an important cause of illness that is underrecognized and, as a result, misdiagnosed. It belongs in the category of chronic inflammatory illnesses with symptoms including fatigue, allergy-like symptoms and problems with virtually every organ system in the body. Dr. Lawrence Afrin is a leading scientist and clinician on mast cell activation syndrome. Dr. Afrin is based out of the University of Minnesota and the author of the book Never Bet Against Occam, a book detailing his clinical experiences and knowledge of this mysterious disease.
Lyme Ninja Radio: Dr. Kelly Halderman - How Mast Cells and Cortisol Keep You sick
Inthis episode you will learn: • What a mast cell actually does • Why you should be careful of forcing you body to produce more energy when its sick • Why managing histamine and cortisol levels are important for long term health Dr. Kelly's Lyme journey started with a diagnosis of Multiple Sclerosis. This began her journey into naturopathic medicine and looking at genetics and other foundational aspects of health. She is a physician in Minnesota and collaborates with Naturopath Bob Miller on understanding the genetic and nutritional components of chronic disease.
Less Stressed Life: Upleveling Life, Health & Happiness: The girl that was allergic to everything: a behind the scenes look at Mast Cell Activation Syndrome with herbalist Lesly Rae
When Lesly Rae started reacting to everything she ate or smelled and spent more of her week in the ER than not, she saw the reality that many Mast Cell Activation Syndrome clients face. It wasn't until she noticed her issues stabilizing from using the elderberry syrup she made each year that she began digging deeper into "healing" vs treating her condition. Today, Lesly has stabilized her condition from "being allergic to everything" to being able to eat whatever she wants and helps others with Mast Cell do the same. This interview sheds important light on a syndrome that is growing but not well understood.
Lyme Ninja Radio: Rob Abbott, MD - The most common Lyme co-infections
In this episode you will learn: • Why mycoplasma is not technically a ‘co-infection’ • A helpful resource for talking to your doctor about potential co-infections • And how the future of disease treatment is immune modulation therapy Rob Abbott is a first year family medicine resident at the Virginia Commonwealth University in Front Royal, Virginia. He graduated from the University of Virginia School of Medicine in 2017. He approaches medicine from an evolutionary and functional perspective and practices what he calls “spiritually focused and evolutionarily informed functional medicine.”
CoreBrain Journal: Dr Lawrence Afrin – Mast Cell Activation Syndrome
Mast Cell Activation Syndrome Answers - If you care about chronic, refractory treatment failure, both medical and psychological/psychiatric - Dr. Afrins message and book here
BetterHealthGuy: Mast Cell Master with Dr. T.C. Theoharides, PhD, MD
Why You Should Listen: Why You Should Listen: In this episode, you will learn about mast cell activation syndrome (MCAS) and some key considerations when treating this common issue seen in those with Lyme disease, mold illness, autism, and other complex conditions. About My Guest: My guest for this episode is Dr. Theo Theoharides. Dr. Theo Theoharides, PhD, MD has studied the regulation of mast cell activation and its role in neuroinflammatory disease for over 30 years. He holds a Masters in Neuroimmunology, a PhD in Pharmacology, and an MD from Yale University. He was the first to report that mast cells can secrete specific mediators selectively without degranulation, regulate blood-brain-barrier permeability, stimulate microglia, be activated by corticotropin-releasing hormone (CRH) secreted under stress to release VEGF selectively, be activated by synergistic action of CRH and neurotensin, be activated by IL-33 and substance P synergistically to secrete the pro-inflammatory cytokine TNF, secrete mitochondrial DNA extracellularly that is mistaken by the body as a pathogen resulting in inflammatory reactions, and communicate with microglia and are involved in inflammation of the brain. He discovered that mast cells are inhibited by certain natural flavonoids, especially luteolin and tetramethoxyluteolin. He has published over 400 peer-reviewed papers and is in the top 5% of authors cited in pharmacological and immunological journals. He is the developer of the well-known liposomal mast cell blocking nutritional supplement known as NeuroProtek and several other products. Key Takeaways: - What is the difference between mastocytosis and mast cell activation syndrome (MCAS)? - What are some conditions where MCAS may play a role? - What are some of the common symptoms of mast cell activation? - How do temperature or season changes impact symptoms? - What are the common triggers of MCAS?- What role does stress play in triggering mast cells? - What are the best ways to approach testing for MCAS? - Can Lyme disease itself be a trigger for mast cells? - What is the link between MCAS and brain fog? - What role does leaky gut play in MCAS? - How do EMFs impact mast cells? - What treatment options might be appropriate in MCAS?
Lyme Ninja Radio: Heather Perretta, MS - Lyme + Mast Cells: Treating beyond the Lyme diagnosis
In this episode you will learn: • What an elemental diet is and how it can help you • How attributing every symptom to Lyme Disease can distract from other underlying issues • What is mast cell activation disorder Heather Perretta is an interpretive naturalist with a Bachelor of Science degree in Environmental and Forest Biology from the State University of New York College of Environmental Science and Forestry. She also holds a master’s degree in Information Design and Technology from the State University of New York Institute of Technology. Heather is a New York State certified biology teacher and is passionate about building a community where people keenly observe their surroundings and understand how we are all connected to nature.
Essentials of Healthy Living: Mast cell activation syndrome (MCAS) – when histamine goes haywire
Dr. Kevin Passero and his special guest Dr. Jill Carnahan will be discussing mast cell activation syndrome (MCAS) – when histamine goes haywire. Dr. Jill Carnahan received her medical degree from Loyola University Stritch School of Medicine in Chicago and completed her residency at the University of Illinois Program in Family Medicine at Methodist Medical Center. She is dually board-certified in Family Medicine (ABFM) and Integrative Holistic Medicine (ABIHM). She was part of the first 100+ healthcare practitioners to be certified through the Institute of Functional Medicine (IFMCP), and recently opened a new medical clinic with a broad range of services in Louisville, Colorado. Dr. Carnahan is also a 14-year survivor of breast cancer and Crohn’s disease and is passionate about teaching patients how to “live well” and thrive in the midst of complex and chronic illness. She is committed to teaching other physicians how to address underlying causes of illness through the principles of functional medicine, rather than just treating symptoms.
Quantum Yoga Podcast: Dr. Tim Jackson on Mast Cell Activation, Detoxification and the Gut
Dr. Tim Jackson, DPT received his undergraduate degree in Health science and chemistry from Wake Forest University in 2003. He completed his Doctorate in Physical Therapy (DPT) from the Medical University of SC in 2009. Realizing that manual therapy and orthopedic care helped only some of his patients, he began studying functional and environmental medicine, as well as digestive health, in an effort to help others achieve wellness. Dr. Tim is educated in nutritional biochemistry, digestive health and its systemic effects, as well as functional endocrinology. He recently completed the Spine portion of the Active Release Technique methodology, a system that addresses musculoskeletal trigger points and helps to expedite the healing process. Currently, Dr. Tim is working on his Functional Diagnostic Nutritionist certification. Dr. Jackson trained with Dr. Kendal Stewart, M.D. to learn the far-reaching implications of methylation deficits and their role in Neuro-immune syndromes. He combines his background in integrative health and wellness with the emerging field of epigenetics to help others. He is a featured doctor for the MTHR Support group of healthcare professionals helping to educate the healthcare community and the public about the role of methylation in both health and dis-ease.
Metagenics Clinical Podcast: The Role of Mast Cells in Female Hormonal Disorders with Dr Tania Dempsey
Dr Tania Dempsey is an expert in chronic disease, autoimmune disorders, mast cell activation syndrome (MCAS), and the role these conditions play in hormonal disorders. Dr Dempsey is sought after internationally for her knowledge of chronic immune dysregulation, and uses Integrative Medicine to get to the root cause of disease.
Angels of the Light: Lyme Disease Alex Hudson Mast Cell Activation Syndrome (MCAS) with Jody Hudson
Alex Hudson was only diagnosed with Lyme Disease in the last year of her life. She carried the disease undiagnosed for 10 years. Doctors were unable to link her symptoms with the disease. Jody explains that dirty ticks carry multiple infectious diseases with them. Not only did Alex have the Lyme disease she carried multiple infections, Babesiosis, Ehrlichiosis, Bartonella, and Rickettsiosis. Each one of the infections carried their own symptoms and problems. If that wasn't bad enough she had Mast Cell Activation Syndrome (MCAS). Alex's mom Jody explains that she never took any pain relievers during the decade of attack. Alex wanted to be totally aware all the time and when it came time. Alex Hudson Lyme Foundation Jody set up the Foundation to extend awareness and education and raise money for Lyme Disease especially Mast Cell Activation Syndrome (MCAS). Jody writes about her daughter's story: On March 24, 2018, the world lost Alex Hudson to Lyme Disease and Mast Cell Activation Syndrome (MCAS). A vibrant 22-year-old girl, Alex had the whole world waiting for her. With a full ride scholarship to UCLA, Alex was eager to further her education and tackle the world with her energetic spirit and vibrant mind. Unfortunately, after a ten-year battle with Lyme and MCAS, her life ended abruptly; leaving a gaping hole in the hearts of everyone whom she met. For nearly a decade, Alex visited countless doctors, underwent numerous tests, received multiple misdiagnoses, and suffered immensely. While many medical professionals often deemed her a “medical mystery,” she never lost hope and finally received a proper Lyme and MCAS diagnosis in 2017. While her family and friends were grateful for concrete answers, many feared the disease had already taken a significant toll on her body. Alex passed away less than a year later. One of Alex’s last wishes was to help educate her community, and help fund proper testing, for those suffering from Lyme and MCAS. After she passed, Alex’s mother, Jody Hudson, and a team of women came together to help form The Alex Hudson Lyme Foundation. Dedicated to spreading awareness and educating others on Lyme and MCAS, the AHLF team is passionate about being advocates for those affected by such a tumultuous disease. If you would like to follow the latest in the foundation be sure to subscribe to the social media accounts.