Mast cell activation syndrome
Mast cell what? Don’t worry, we don’t blame you if you haven’t heard of it! First, let’s talk mast cells. Mast cells are a type of immune cell that originate in the bone marrow and are found in most tissues. They play a role in both health and disease, and are most commonly known for their role in atopic disorders (aka allergies) and anaphylaxis. When they’re functioning normally, mast cells release chemicals that help protect the body—they’re like first responders for your immune system. But when they’re not properly regulated, mast cells have been linked to several chronic allergic/inflammatory disorders, autoimmune diseases, and cancers. If you have mast cell activation syndrome (MCAS), your mast cells overreact and release chemicals when they shouldn’t. Often, they treat food, fragrances, temperature, and even stress as something to “defend against.” Depending on which chemical the mast cells release, you can experience a whole range of symptoms, including hives, diarrhea, shortness of breath, fatigue, brain fog, congestion, lightheadedness, and much more. MCAS may even cause anaphylaxis, a medical emergency. And it may pop up in people who have Ehlers Danlos Syndrome (EDS), which is a connective tissue disorder, or Postural Orthostatic Tachycardia Syndrome (POTS). MCAS is difficult to diagnose and treatment response varies. If you have MCAS, try to avoid substances and environments that may provoke your symptoms. If a severe anaphylactic reaction occurs, call 911 right away—you’ll need to be treated emergently with epinephrine. Antihistamines, H2 blockers, mast cell stabilizers, and steroids are also used to help treat the symptoms. Your mast cells are just trying to do their job and keep you safe, but as is often the case, the immune system can take it too far!
Recent posts about Mast cell activation syndrome
Anyone in the South Jersey/Philadelphia are on low dose naltrexone? I have a referral for it, but I need to find a specialist who can prescribe it. any suggestions? especially if they’re familiar with EDS, POTS, MCAS &co.
I went out for the first time in months to PT and I think my mask/lack of oxygen gave me an MCAS flare?!?!! I was itchy, had livedo reticularis, cold hands and a headache. Any one have an experience like this?
Because of mast cell activation syndrome I can’t take NSAIDs. Which left me with few pain relief options for period cramps. Unfortunately I even became sensitive to all the herbs that helped. So CBD was the only thing that helped. My doctor recommended Benadryl for cramps, and it works! I thought I would share in case anyone is in a similar place.
Videos about Mast cell activation syndrome
MAST CELL ACTIVATION SYNDROME TREATMENT SUCCESS WITH STEM CELL: 7-Revolutionary Breakthroughs!
Dr. Michael Johnson
Books about Mast cell activation syndrome
Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity
In 2008 Dr. Afrin started coming to understand that a newly recognized type of mast cell disease, now called mast cell activation syndrome (MCAS), was the underlying diagnosis in many patients he was seeing who were each suffering large assortments -- quite different from one patient to the next -- of chronic multisystem inflammatory illnesses of unclear cause. Dr. Afrin soon gained experience that MCAS is far more prevalent than the only mast cell disease previously known to medicine (the rare disease of mastocytosis) and that most MCAS patients, once accurately diagnosed, can eventually find significantly helpful medications targeted at the disease. The frequency and magnitude of the improvements Dr. Afrin has seen -- even the relief that comes from finally having a unifying diagnosis other than psychosomatism -- have spurred him to focus in this area, not only tending to the needs of his patients but also pursuing research to advance our understanding of the disease and helping to educate other professionals who in turn can help even more of the many people who have long been suffering not only the symptoms of the disease but also the natural concern of not understanding why one would be so "unlucky" to have acquired so many medical problems. As it turns out, such patients are not so unlucky and truly have just one root issue (and a very common one at that), which has the biological capability to develop, directly or indirectly, into most or all of their previously diagnosed problems. There is a great deal yet to learn about this, but even with just the present very limited understanding, the opportunity to diagnose and help patients with MCAS seems to be enormous and Dr. Afrin felt a description of the disease, written for the general public, might help lead some MCAS patients on a journey to diagnosis and improvement sooner rather than later. Dr. Afrin hopes this book will help people who might have, or do have, MCAS. A portion of the proceeds of purchases of this book will go to support research and education in this area.
Podcasts about Mast cell activation syndrome
Dr. Ruscio Radio: Could Mast Cell Activation Syndrome Be the Cause of Your Non-Responsive Symptoms? Simplified Assessment and Treatment Recommendations with Dr. Tania Dempsey
Mast Cell Activation Syndrome (MCAS) is something to consider when you haven’t responded to anything else. Let’s discuss simple methods of treatment and assessment. Specifically a simple questionnaire and a small number of natural or over the counter medications may make a big difference in improving how you feel if you haven’t responded to other treatments you have tried. https://drruscio.com/mcas-symptoms-with-tania-demp… My new book is finally available: Healthy Gut, Healthy You. Click here to learn more: https://drruscio.com/getgutbook/ Looking for more? Check out our resource page that includes how to become a patient, how to pick up a copy of my new book, how to sign up for my clinical training newsletter, and more.
Dr. Ruscio Radio: Histamine Intolerance & Mast Cell Activation Syndrome (MCAS) with Dr. Jill Carnahan
If you feel like you react to everything you eat or take, or you can’t improve no matter what you do, you should consider the possibility of histamine intolerance and/or mast cell activation syndrome. Today Dr. Jill Carnahan and I expand on how to identify histamine intolerance and/or mast cell activation syndrome and some simple steps you can take to address these issues
The SIBO Doctor: SIBO and Mast Cell Activation Syndrome
In this episode, Dr Nirala Jacobi speaks with Heidi Turner on the topic of Mast Cell Activation Syndrome. Heidi is a medical nutrition therapist at the Seattle Arthritis Clinic at Northwest Hospital UW Medicine in Seattle, Washington. She specialises in food intolerances, SIBO, and other digestive disorders, addressing the digestion in order to balance all body systems. In this episode topics include: Using diet to decrease inflammation in the body and improve pain markers for autoimmune patients. Mast cell activation syndrome (MCAS) and the diverse array of signs and symptoms with which it can present. SIBO and how it relates to mast cells disorder and MCAS. What mast cells are and what responses they create within the immune system. Predisposing factors for MCAS The physiological relationship of stressors, and/or emotional trauma to the development of MCAS and other conditions in the body. Histamine Its diverse roles in the body. Intolerance symptoms. How intolerance can develop. High histamine foods. How to best assess patients for histamine intolerance. Antihistamine supplements. Diamine Oxidase (DAO) and SIBO related histamine dysregulation. How to navigate probiotic treatment for highly digestively sensitive patients. Various treatment options for stabilising mast cells, and MCAS specific support.
Sickboy: Slayer of Dragons, Mast Cells & Ehlers-Danlos Syndromes
This week on Sickboy the guys sit down with an 18 year old Knight in shining armour. Literally. Danielle lives with a Mast Cell and Ehlers-Danlos syndrome but that doesn’t stop her from taking part in medieval battles. We dive into the world of L.A.R.P and Brian geeks out a little too much on World of Warcraft. Danielle reminds us of the importance of developing and seeking community in times of need. Oh, and one more thing a real life opera singer stops the studio for a show.
New Frontiers in Functional Medicine: All things Mast Cell with World-Renowned Clinical Researcher Dr. Theoharides
In my Tour de Force conversation with the brilliant Dr. Theoharis Theoharides, we covered all things mast cells, from “bench to bedside.” In case you have not yet encountered his work yet, he is one of the most highly decorated, well-published clinician researchers in the world. The focus of his life’s work has been on all things mast cells, and mast cell associated conditions. Given the meteoric rise in said conditions (and our improved understanding of the role of mast cells in most chronic diseases), as clinicians, we need to understand how to diagnose and treat. Buckle up for this podcast, and get your pen and pad ready – the depth and breadth of Dr. T’s knowledge requires careful listening. Give a listen, then give a thumbs up for this brilliant, generous clinician!
- The American Academy of Allergy Asthma & Immunology. Mast Cell Activation Syndrome. The American Academy of Allergy Asthma & Immunology. Mast Cell Activation Syndrome.
- Immunology and Allergy Clinics of North America. Mast cell mediators in allergic inflammation and mastocytosis. Immunology and Allergy Clinics of North America. Mast cell mediators in allergic inflammation and mastocytosis.
- International Archives of Allergy and Immunology. Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal. International Archives of Allergy and Immunology. Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal.
- International Archives of Allergy and Immunology. Prevention of mast cell activation disorder-associated clinical sequelae of excessive prostaglandin D(2) production. International Archives of Allergy and Immunology. Prevention of mast cell activation disorder-associated clinical sequelae of excessive prostaglandin D(2) production.
- New England Journal of Medicine. Mast Cells, Mastocytosis, and Related Disorders. New England Journal of Medicine. Mast Cells, Mastocytosis, and Related Disorders.